AIPMT PRELIMS2009Zoology-Human Health and Disease
AIPMT PRELIMS 2009 Zoology Genetic Disorders MCQ Question
Type: MCQ-conceptual-Medium-Class 12
Sickle cell anemia is:
A
caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
B
caused by a change in a single base pair of DNA
C
characterized by elongated sickle like RBCs with a nucleus
D
an autosomal linked dominant trait
Correct Answer
Option B
Detailed Explanation
Sickle cell anemia is caused by a single base pair mutation in the DNA, leading to the substitution of valine for glutamic acid in the hemoglobin molecule.
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