AIPMT MAIN 2008 Chemistry Acyl Compounds MCQ Question
The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of
Acyl chloride > Ester > Acid anhydride > Amide
Acyl chloride > Acid anhydride > Ester > Amide
Ester > Acyl chloride > Amide > Acid anhydride
Acid anhydride > Amide > Ester > Acyl chloride
Correct Answer
Detailed Explanation
Better is the leaving group higher will be the reactivity of acyl compounds towards nucleophilic acyl substitution. Weaker is the base, better is the leaving group. Weaker bases are derived from stronger acids.
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