AIIMS 2019 Chemistry Reductive Amination and Transamination MCQ Question
Assertion: Reductive amination involves the transfer of amino group from one amino acid to the keto group of a keto acid.
Reason: In transmission reaction, ammonia reacts with α- ketoglutaric acid and forms glutamic acid.
If both assertion and reason are true and reason is the correct explanation of assertion.
If both assertion and reason are true but reason is not the correct explanation of assertion.
If assertion is true but reason is false.
If both assertion and reason are false.
Correct Answer
Detailed Explanation
In reductive amination, ammonia (NH₃) reacts with α-ketoglutaric acid (α-KG) in the presence of glutamate dehydrogenase and reduced coenzymes like NADH or NADPH to form glutamate, an amino acid. This process differs from transamination, where an amino group (−NH₂) is transferred from one amino acid to a keto acid, facilitated by transaminases or aminotransferases. Since option C likely pertains to the correct description of reductive amination or transamination, it is the appropriate choice, while the other options (A, B, D) do not provide relevant information or context related to these biochemical processes.
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